Biological Applications of Short Wavelength Microscopy Based on Compact, Laser-Produced Gas-Puff Plasma Source

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F20%3A00538338" target="_blank" >RIV/61389005:_____/20:00538338 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.3390/app10238338" target="_blank" >https://doi.org/10.3390/app10238338</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/app10238338" target="_blank" >10.3390/app10238338</a>

Result language

angličtina

Original language name

Biological Applications of Short Wavelength Microscopy Based on Compact, Laser-Produced Gas-Puff Plasma Source

Original language description

Short wavelength compact microscopy setups, operating in the biological-dedicated 'water window' spectral range, perform sample imaging with a nanometer spatial resolution, employing complementary tools to the existing imaging techniques.nnOver the last decades, remarkable efforts have been made to improve the resolution in photon-based microscopes. The employment of compact sources based on table-top laser-produced soft X-ray (SXR) in the 'water window' spectral range (lambda = 2.3-4.4 nm) and extreme ultraviolet (EUV) plasma allowed to overcome the limitations imposed by large facilities, such as synchrotrons and X-ray free electron lasers (XFEL), because of their high complexity, costs, and limited user access. A laser-plasma double stream gas-puff target source represents a powerful tool for microscopy operating in transmission mode, significantly improving the spatial resolution into the nanometric scale, comparing to the traditional visible light (optical) microscopes. Such an approach allows generating the plasma efficiently, without debris, providing a high flux of EUV and SXR photons. In this review, we present the development and optimization of desktop imaging systems: a EUV and an SXR full field microscope, allowing to achieve a sub-50 nm spatial resolution with short exposure time and an SXR contact microscope, capable to resolve internal structures in a thin layer of sensitive photoresist. Details about the source, as well as imaging results for biological applications, will be presented and discussed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10306 - Optics (including laser optics and quantum optics)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Sciences-Basel

ISSN

2076-3417

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

23

Country of publishing house

CH - SWITZERLAND

Number of pages

32

Pages from-to

8338

UT code for WoS article

000597110900001

EID of the result in the Scopus database

2-s2.0-85096575011