Experimental in vitro dosimetry of 223Ra and 177Lu

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F22%3A00560657" target="_blank" >RIV/61389005:_____/22:00560657 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21340/22:00359544

Result on the web

<a href="https://doi.org/10.1093/rpd/ncac090" target="_blank" >https://doi.org/10.1093/rpd/ncac090</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rpd/ncac090" target="_blank" >10.1093/rpd/ncac090</a>

Result language

angličtina

Original language name

Experimental in vitro dosimetry of 223Ra and 177Lu

Original language description

Targeted alpha therapy with radionuclides undergoing multiple alpha-particle decays is a promising method of nuclear medicine. To study the effectiveness of alpha versus beta emitters, survival of DU145 prostate cancer cells exposed to Ra-223 or Lu-177 was assessed. Per decay, the cells were much more sensitive to the alpha than beta emitter. However, per unit dose the sensitivities would be comparable, contrary to the well-known evidence, if the decay energy were deposited within the sample completely and homogeneously. Measurements by Timepix detectors showed about three times higher counts of alpha particles above than below the sample. After the first alpha decay of Ra-223 to Rn-219, this gas likely moves upwards and its subsequent three alpha decays occur in the upper part of the sample. Correct estimation of absorbed dose is a critical issue when analysing in vitro data and when translating their results to clinical applications.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

<a href="/en/project/TJ04000129" target="_blank" >TJ04000129: Separation of radionuclides for targeted alpha particle therapy</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation Protection Dosimetry

ISSN

0144-8420

e-ISSN

1742-3406

Volume of the periodical

198

Issue of the periodical within the volume

9-11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

508-513

UT code for WoS article

000844405700003

EID of the result in the Scopus database

2-s2.0-85160102787