Preliminary In-vitro Study of 223Ra Impact on Selected Tissue and Tumor Cell Lines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F19%3A00332744" target="_blank" >RIV/68407700:21340/19:00332744 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jmir.2019.03.125" target="_blank" >http://dx.doi.org/10.1016/j.jmir.2019.03.125</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmir.2019.03.125" target="_blank" >10.1016/j.jmir.2019.03.125</a>
Alternative languages
Result language
angličtina
Original language name
Preliminary In-vitro Study of 223Ra Impact on Selected Tissue and Tumor Cell Lines
Original language description
Targeted alpha-particle therapy (TAT) is very rapidly evolving field of radionuclide therapy. Nevertheless, there are some severe issues that need to be addressed to enable TAT to be a leading modality in radionuclide therapy. The nuclear recoil effect that causes the daughter nuclei release from the original radiopharmaceuticals is critical for alpha emitters. Moreover, targeting and proper dosimetry is still an issue. Therefore, it is very important to understand the dosimetry both on cellular and subcellular level. The first step of each dosimetric study is the determination of survival curves. For our preliminary study we used Ra-223 as a model alpha-emitting nuclide. Selected cell lines were V79 (Chinese hamster lung fibroblasts), DU145 (human adenocarcinoma cell line) and U87 (human primary glioblastoma cell line) obtained from American Type Culture Collection (ATCC). All obtained survival curves correspond to the linearly quadratic model. Sensitivity of both human carcinoma cell lines (adenocarcinoma and glioblastoma cell line) to Ra-223 treatment is higher than the sensitivity of Chinese hamster cell line. Preliminary results indicates higher radiosensitivity of DU145 and U87 against V79 cells. The achieved results enabled further progress in enhancing the dosimetric knowledge.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů