Evaluating the Relevance of Non-invasive Measurement of Protein Synthesis by Gallium-68-DOTA-puromycin PET/MRI for Imaging of Mycobacterial Infection - a Preclinical Report

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F23%3A00579002" target="_blank" >RIV/61389005:_____/23:00579002 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s00259-023-06333-x" target="_blank" >https://doi.org/10.1007/s00259-023-06333-x</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Evaluating the Relevance of Non-invasive Measurement of Protein Synthesis by Gallium-68-DOTA-puromycin PET/MRI for Imaging of Mycobacterial Infection - a Preclinical Report
Original language description
Puromycin is a relevant scafold for the development of a radiopharmaceutical that will allow the quantifcation of protein synthesis non-invasively through nuclear based imaging techniques. A signifcant clinical application of radiolabeled puromycin depends on the visualization of mycobacterial protein synthesis for future clinical investigations of tuberculous lesions. To date, no systematic characterization of a puromycin-based radiopharmaceuticals as potential in vivo infection imaging agents has been reported. Therefore, this study will address selectivity, sensitivity, and accuracy of [68Ga]Ga-DOTA-puromycin-micro-positron emission tomography combined with magnetic resonance imaging (microPET/MRI) imaging to determine the role and value of this technique to detect mycobacterial infection in vivo.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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