Variations among glioblastoma cell lines in boron-mediated enhancement of cell killing by proton beams
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F25%3A00638313" target="_blank" >RIV/61389005:_____/25:00638313 - isvavai.cz</a>
Alternative codes found
RIV/00177016:_____/25:N0000089 RIV/00064211:_____/25:W0000073
Result on the web
<a href="https://www.nature.com/articles/s41598-025-14658-w" target="_blank" >https://www.nature.com/articles/s41598-025-14658-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-14658-w" target="_blank" >10.1038/s41598-025-14658-w</a>
Alternative languages
Result language
angličtina
Original language name
Variations among glioblastoma cell lines in boron-mediated enhancement of cell killing by proton beams
Original language description
Enhancement in cell killing by proton beams in the presence of boron (natural mixture natB: 80% 11B, 20% 10B) was reported, selectively in the Bragg peak region, putatively due to the proton-11B capture reaction. However, as some groups observed no such enhancement or assigned it to secondary neutron-10B capture, proton-boron capture therapy (PBCT) remains controversial. We previously validated this concept for U-87 MG glioblastoma cells. To test its generality and potential applicability for these tumours, we assessed PBCT using three further cell lines widely used in glioblastoma research. In U251 cells, natB enhanced cell killing by protons in Bragg peak but also in plateau regions, effects of 10B were even higher, and were found also for 18MV but not 6 MV photon beams (above and below photo-neutron production thresholds, respectively), suggesting a key role of secondary neutrons. For A172 and T98G cells, no enhancement was found at all. This variability among cell lines may stem from differences in boron uptake and/or in intercellular signalling likely needed to amplify the initial events in a few hit cells to population-level effects. Together with recent negative studies, the results suggest that potential clinical applications of PBCT are less promising than originally thought.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/GA21-06451S" target="_blank" >GA21-06451S: Puzzling enhancement of proton-induced cellular damage by boron</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
29453
UT code for WoS article
001548644500004
EID of the result in the Scopus database
2-s2.0-105013258275