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Protein-containing PEGylated cubosomic particles: freeze-fracture electron microscopy and synchrotron radiation circular dichroism study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F12%3A00378735" target="_blank" >RIV/61389013:_____/12:00378735 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1021/jp303863q" target="_blank" >http://dx.doi.org/10.1021/jp303863q</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/jp303863q" target="_blank" >10.1021/jp303863q</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Protein-containing PEGylated cubosomic particles: freeze-fracture electron microscopy and synchrotron radiation circular dichroism study

  • Original language description

    The entrapment of protein molecules in cubosomic nanocarriers that are sterically stabilized by an amphiphilic poly(ethylene glycol) (PEG) derivative are investigated. The mechanism of fragmentation of a self-assembled PEGylated cubic lipid phase into nanoparticles (NPs) is studied in excess aqueous medium. The molar ratio between the cubic-phase-forming lipid monoolein (MO) and its PEGylated derivative (MOPEG2000) is selected as to favor the formation of inverted-type liquid-crystalline (LC) structures. Freeze-fracture electron microscopy (FF-EM), quasi-elastic light scattering (QELS), confocal laser scanning fluorescence microscopy (CLSFM) and far-UV synchrotron radiation circular dichroism (SRCD) spectroscopy are applied for determination of the NPs' sizes, inner organization, stability, and interaction with the protein ?-chymotrypsinogen A. The PEGylated cubosomes offer new possibilities for investigation of protein loading in sterically stabilized (?Stealth) lipid carriers.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP208%2F10%2F1600" target="_blank" >GAP208/10/1600: Polymeric particles and nanostructured materials stabilized by surface active molecules</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Physical Chemistry B

  • ISSN

    1520-6106

  • e-ISSN

  • Volume of the periodical

    116

  • Issue of the periodical within the volume

    26

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    7676-7686

  • UT code for WoS article

    000305933800009

  • EID of the result in the Scopus database