Protein entrapment in PEGylated lipid nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00394935" target="_blank" >RIV/61389013:_____/13:00394935 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijpharm.2013.06.006" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2013.06.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2013.06.006" target="_blank" >10.1016/j.ijpharm.2013.06.006</a>

Result language
angličtina
Original language name
Protein entrapment in PEGylated lipid nanoparticles
Original language description
Defining appropriate delivery strategies of therapeutic proteins, based on lipid nanoparticulate carriers, requires knowledge of the nanoscale organization that determines the loading and release properties of the nanostructured particles. Nanoencapsulation of three cationic proteins (human brain-derived neurotrophic factor (BDNF), ?-chymotrypsinogen A, and histone H3) was investigated using anionic nanoparticle (NP) carriers. PEGylated lipid NPs were prepared from self-assembled liquid crystalline phases involving monoolein and eicosapentaenoic acid. Inclusion of the antioxidant ?-tocopherol favoured the preparation of stealth hexosome carriers. The purpose of the present work is to reveal the structural features of the protein-loaded lipid nanocarriers by means of high resolution small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM). The obtained results indicate that protein entrapment is concentration-dependent and may significantly modify th
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP208%2F10%2F1600" target="_blank" >GAP208/10/1600: Polymeric particles and nanostructured materials stabilized by surface active molecules</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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