Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00398411" target="_blank" >RIV/61389013:_____/13:00398411 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/bm401186z" target="_blank" >http://dx.doi.org/10.1021/bm401186z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/bm401186z" target="_blank" >10.1021/bm401186z</a>

Result language
angličtina
Original language name
Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study
Original language description
We report kinetic studies of therapeutically highly potent polymerdrug conjugates consisting of amphiphilic N-(2-hydroxypropyl) methacrylamide (HPMA)-based copolymers bearing the anticancer drug doxorubicin (Dox). Highly hydrophobic cholesterol moietiesas well as the drug were attached to the polymer backbone by a pH-sensitive hydrazone bond. Moreover, the structure of the spacer between the polymer carrier and the cholesterol moiety differed in order to influence the release rate of the hydrophobic moiety, and thus the disintegration of the highmolecular-weight micellar nanoparticle structure.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP208%2F10%2F1600" target="_blank" >GAP208/10/1600: Polymeric particles and nanostructured materials stabilized by surface active molecules</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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