Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00442140" target="_blank" >RIV/61389013:_____/15:00442140 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jmmm.2014.09.037" target="_blank" >http://dx.doi.org/10.1016/j.jmmm.2014.09.037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmmm.2014.09.037" target="_blank" >10.1016/j.jmmm.2014.09.037</a>

Result language
angličtina
Original language name
Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity
Original language description
Maghemite (?-Fe2O3) nanoparticles were obtained by co-precipitation of Fe(II) and Fe(III) chlorides and subsequent oxidation with sodium hypochlorite and coated with poly(N,N-dimethylacrylamide-co-acrylic acid) [P(DMAAm-AA)]. They were characterized by arange of methods including transmission electron microscopy (TEM), elemental analysis, dynamic light scattering (DLS) and zeta potential measurements. The effect of superparamagnetic P(DMAAm-AA)-?-Fe2O3 nanoparticles on oxidation of blood lipids, glutathione and proteins in blood serum was detected using 2-thiobarbituric acid and the ThioGlo fluorophore. Finally, mice received magnetic nanoparticles administered per os and the antitumor activity of the particles was tested on Lewis lung carcinoma (LLC)in male mice line ?57?L/6 as an experimental in vivo metastatic tumor model; the tumor size was measured and the number of metastases in lungs was determined. Surface-modified ?-Fe2O3 nanoparticles showed higher antitumor and antimetasta
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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