Enhanced antitumor activity of surface-modified iron oxide nanoparticles and an .alpha.-tocopherol derivative in a rat model of mammary gland carcinosarcoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00475035" target="_blank" >RIV/61389013:_____/17:00475035 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2147/IJN.S137574" target="_blank" >http://dx.doi.org/10.2147/IJN.S137574</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/IJN.S137574" target="_blank" >10.2147/IJN.S137574</a>

Result language

angličtina

Original language name

Enhanced antitumor activity of surface-modified iron oxide nanoparticles and an .alpha.-tocopherol derivative in a rat model of mammary gland carcinosarcoma

Original language description

Maghemite (.gamma.-Fe2O3) nanoparticles were obtained by coprecipitation of ferrous and ferric salts in an alkaline medium followed by oxidation. The nanoparticles were coated with poly(N,N-dimethylacrylamide) (PDMA) and characterized by transmission electron microscopy, attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering, thermogravimetric and elemental analyses, and magnetic measurements in terms of particle morphology, size, polydispersity, amount of coating, and magnetization, respectively. The effects of .alpha.-tocopherol (Toc) and its phenolic (Toc-6-OH) and acetate (Toc-6-Ac) derivatives on Fe2+ release from .gamma.-Fe2O3@PDMA, as well as from .gamma.-Fe2O3 and CuFe2O4 nanoparticles (controls), were examined in vitro using 1,10-phenanthroline. The presence of tocopherols enhanced spontaneous Fe2+ release from nanoparticles, with Toc-6-OH exhibiting more activity than neat Toc. All of the nanoparticles tested were found to initiate blood lipid oxidation in a concentration-dependent manner, as determined by analysis of 2-thiobarbituric acid reactive species. Wistar rats with Walker-256 carcinosarcoma (a model of mammary gland carcinosarcoma) received Toc-6-Ac, magnetic nanoparticles, or their combination per os, and the antitumor activity of each treatment was determined in vivo. .gamma.-Fe2O3@PDMA nanoparticles exhibited increased antitumor activity compared to both commercial CuFe2O4 particles and the antitumor drug doxorubicin. Moreover, increased antitumor activity was observed after combined administration of .gamma.-Fe2O3@PDMA nanoparticles and Toc-6-Ac. However, levels of bilirubin, aspartate aminotransferase, and white bloods normalized and did not differ from those of the intact controls. The antitumor activity of the .gamma.-Fe2O3 nanoparticles strongly correlated with Fe2+ release from the nanoparticles but not with nanoparticle-initiated lipid peroxidation in vitro.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/GA17-04918S" target="_blank" >GA17-04918S: Treating Glioblastoma with surface engineered superparamagnetic iron oxide nanoparticles for efficient conjugation with anticancer drugs</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Nanomedicine

ISSN

1178-2013

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

6 June

Country of publishing house

NZ - NEW ZEALAND

Number of pages

12

Pages from-to

4257-4268

UT code for WoS article

000402928500002

EID of the result in the Scopus database

2-s2.0-85020426594