Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00444229" target="_blank" >RIV/61389013:_____/15:00444229 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jconrel.2015.05.265" target="_blank" >http://dx.doi.org/10.1016/j.jconrel.2015.05.265</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jconrel.2015.05.265" target="_blank" >10.1016/j.jconrel.2015.05.265</a>

Result language
angličtina
Original language name
Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours
Original language description
Nanomedicines have provided fresh impetus in the fight against cancer due to their selectivity and power. However, these agents are limited when delivered intravenously due to their rapid clearance from the bloodstream and poor passage from the bloodstream into target tumours. Here we describe a novel stealthing strategy which addresses both these limitations and thereby demonstrate that both the passive and mechanically-mediated tumour accumulation of the model nanomedicine adenovirus (Ad) can be substantially enhanced. In our strategy gold nanoparticles were thoroughly modified with 2 kDa polyethyleneglycol (PEG) and then linked to Ad via a single reduction-cleavable 5 kDa PEG. The resulting Ad?gold?PEG construct was compared to non-modified Ad or conventionally stealthed Ad?poly[N-(2-hydroxypropyl)methacrylamide] (Ad?PHPMA). Notably, although Ad?gold?PEG was of similar size and surface charge to Ad?PHPMA the increase in density, resulting from the inclusion of the gold nanoparticles
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
<a href="/en/project/EE2.3.30.0029" target="_blank" >EE2.3.30.0029: BIOPOL: BIOpolymer POstdoc Laboratory and educative center</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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