Coating persistent luminescence nanoparticles with hydrophilic polymers for in vivo imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00532405" target="_blank" >RIV/61389013:_____/20:00532405 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fchem.2020.584114/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fchem.2020.584114/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fchem.2020.584114" target="_blank" >10.3389/fchem.2020.584114</a>
Alternative languages
Result language
angličtina
Original language name
Coating persistent luminescence nanoparticles with hydrophilic polymers for in vivo imaging
Original language description
Persistent luminescence nanoparticles (PLNPs) are innovative nanomaterials highly useful for bioimaging applications. Indeed, due to their particular optical properties, i.e., the ability to store the excitation energy before slowly releasing it for a prolonged period of time, they allow in vivo imaging without auto-fluorescence and with a high target to background ratio. However, as for most nanoparticles (NPs), without any special surface coating, they are rapidly opsonized and captured by the liver after systemic injection into small animals. To overcome this issue and prolong nanoparticle circulation in the bloodstream, a new stealth strategy was developed by covering their surface with poly(N-2-hydroxypropyl)methacrylamide (pHPMA), a highly hydrophilic polymer widely used in nanomedicine. Preliminary in vivo imaging results demonstrated the possibility of pHPMA as an alternative strategy to cover ZnGa2O4:Cr NPs to delay their capture by the liver, thereby providing a new perspective for the formulation of stealth NPs.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Chemistry
ISSN
2296-2646
e-ISSN
—
Volume of the periodical
8
Issue of the periodical within the volume
24 September
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000576023700001
EID of the result in the Scopus database
2-s2.0-85092310141