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Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00450082" target="_blank" >RIV/61389013:_____/15:00450082 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1021/acs.biomac.5b01224" target="_blank" >http://dx.doi.org/10.1021/acs.biomac.5b01224</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/acs.biomac.5b01224" target="_blank" >10.1021/acs.biomac.5b01224</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids)

  • Original language description

    We present an investigation of the preparation of highly porous hydrogels based on biodegradable synthetic poly(?-amino acid) as potential tissue engineering scaffolds. Covalently cross-linked gels with permanent pores were formed under cryogenic conditions by free-radical copolymerization of poly[N5-(2-hydroxyethyl)-l-glutamine-stat-N5-(2-methacryloyl-oxy-ethyl)-l-glutamine] (PHEG-MA) with 2-hydrohyethyl methacrylate (HEMA) and, optionally, N-propargyl acrylamide (PrAAm) as minor comonomers. The morphology of the cryogels showed interconnected polyhedral or laminar pores. The volume content of communicating water-filled pores was >90%. The storage moduli of the swollen cryogels were in the range of 1?6 kPa, even when the water content was >95%. The enzymatic degradation of a cryogel corresponded to the decrease in its storage modulus during incubation with papain, a model enzyme with specificity analogous to wound-healing enzymes. It was shown that cryogels with incorporated alkyne gr

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CD - Macromolecular chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP108%2F12%2F1538" target="_blank" >GAP108/12/1538: MICROSTRUCTURED HYDROGELS FOR TISSUE ENGINEERING: VISCOELASTIC RESPONSES OF GELS OF VARIOUS MORHOLOGIES.</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomacromolecules

  • ISSN

    1525-7797

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    3455-3465

  • UT code for WoS article

    000364614300005

  • EID of the result in the Scopus database

    2-s2.0-84946763643