Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00450082" target="_blank" >RIV/61389013:_____/15:00450082 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/acs.biomac.5b01224" target="_blank" >http://dx.doi.org/10.1021/acs.biomac.5b01224</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.5b01224" target="_blank" >10.1021/acs.biomac.5b01224</a>
Alternative languages
Result language
angličtina
Original language name
Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids)
Original language description
We present an investigation of the preparation of highly porous hydrogels based on biodegradable synthetic poly(?-amino acid) as potential tissue engineering scaffolds. Covalently cross-linked gels with permanent pores were formed under cryogenic conditions by free-radical copolymerization of poly[N5-(2-hydroxyethyl)-l-glutamine-stat-N5-(2-methacryloyl-oxy-ethyl)-l-glutamine] (PHEG-MA) with 2-hydrohyethyl methacrylate (HEMA) and, optionally, N-propargyl acrylamide (PrAAm) as minor comonomers. The morphology of the cryogels showed interconnected polyhedral or laminar pores. The volume content of communicating water-filled pores was >90%. The storage moduli of the swollen cryogels were in the range of 1?6 kPa, even when the water content was >95%. The enzymatic degradation of a cryogel corresponded to the decrease in its storage modulus during incubation with papain, a model enzyme with specificity analogous to wound-healing enzymes. It was shown that cryogels with incorporated alkyne gr
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP108%2F12%2F1538" target="_blank" >GAP108/12/1538: MICROSTRUCTURED HYDROGELS FOR TISSUE ENGINEERING: VISCOELASTIC RESPONSES OF GELS OF VARIOUS MORHOLOGIES.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomacromolecules
ISSN
1525-7797
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
3455-3465
UT code for WoS article
000364614300005
EID of the result in the Scopus database
2-s2.0-84946763643