Antifouling polymer brushes displaying antithrombogenic surface properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00458015" target="_blank" >RIV/61389013:_____/16:00458015 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/acs.biomac.6b00019" target="_blank" >http://dx.doi.org/10.1021/acs.biomac.6b00019</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.6b00019" target="_blank" >10.1021/acs.biomac.6b00019</a>
Alternative languages
Result language
angličtina
Original language name
Antifouling polymer brushes displaying antithrombogenic surface properties
Original language description
The contact of blood with artificial materials generally leads to immediate protein adsorption (fouling), which mediates subsequent biological processes such as platelet adhesion and activation leading to thrombosis. Recent progress in the preparation of surfaces able to prevent protein fouling offers a potential avenue to mitigate this undesirable effect. In the present contribution, we have prepared several types of state-of-the-art antifouling polymer brushes on polycarbonate plastic substrate, and investigated their ability to prevent platelet adhesion and thrombus formation under dynamic flow conditions using human blood. Moreover, we compared the ability of such brushes-grafted on quartz via an adlayer analogous to that used on polycarbonate-to prevent protein adsorption from human blood plasma, assessed for the first time by means of an ultrahigh frequency acoustic wave sensor. Results show that the prevention of such a phenomenon constitutes one promising route toward enhanced resistance to thrombus formation, and suggest that antifouling polymer brushes could be of service in biomedical applications requiring extensive blood-material surface contact.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomacromolecules
ISSN
1525-7797
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1179-1185
UT code for WoS article
000372391800051
EID of the result in the Scopus database
2-s2.0-84960877090