The relation between protein adsorption and hemocompatibility of antifouling polymer brushes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00564084" target="_blank" >RIV/61389013:_____/22:00564084 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/22:00013438 RIV/60076658:12310/22:43905325

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200247" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200247</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mabi.202200247" target="_blank" >10.1002/mabi.202200247</a>

Result language

angličtina

Original language name

The relation between protein adsorption and hemocompatibility of antifouling polymer brushes

Original language description

Whenever an artificial surface comes into contact with blood, proteins are rapidly adsorbed onto its surface. This phenomenon, termed fouling, is then followed by a series of undesired reactions involving activation of complement or the coagulation cascade and adhesion of leukocytes and platelets leading to thrombus formation. Thus, considerable efforts are directed towards the preparation of fouling-resistant surfaces with the best possible hemocompatibility. Herein, a comprehensive hemocompatibility study after heparinized blood contact with seven polymer brushes prepared by surface-initiated atom transfer radical polymerization is reported. The resistance to fouling is quantified and thrombus formation and deposition of blood cellular components on the coatings are analyzed. Moreover, identification of the remaining adsorbed proteins is performed via mass spectroscopy to elucidate their influence on the surface hemocompatibility. Compared with an unmodified glass surface, the grafting of polymer brushes minimizes the adhesion of platelets and leukocytes and prevents the thrombus formation. The fouling from undiluted blood plasma is reduced by up to 99%. Most of the identified proteins are connected with the initial events of foreign body reaction towards biomaterial (coagulation cascade proteins, complement component, and inflammatory proteins). In addition, several proteins that are not previously linked with blood-biomaterial interaction are presented and discussed.n

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10610 - Biophysics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Macromolecular Bioscience

ISSN

1616-5187

e-ISSN

1616-5195

Volume of the periodical

22

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

2200247

UT code for WoS article

000837814700001

EID of the result in the Scopus database

2-s2.0-85135602066