Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe3O4&SiO2 core–shell nanoparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00470671" target="_blank" >RIV/61389013:_____/17:00470671 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/C7RA00224F" target="_blank" >http://dx.doi.org/10.1039/C7RA00224F</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C7RA00224F" target="_blank" >10.1039/C7RA00224F</a>

Result language

angličtina

Original language name

Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe3O4&SiO2 core–shell nanoparticles

Original language description

Monodisperse, superparamagnetic oleic acid-stabilized Fe3O4 nanoparticles of different sizes were prepared by thermal decomposition of Fe(III) oleate. The particles were subsequently coated by silica shells of different thicknesses (yielding Fe3O4&SiO2) using a water-in-oil (w/o) reverse microemulsion technique and/or were decorated with amino groups by reaction with (3-aminopropyl)triethoxysilane. The resulting Fe3O4&SiO2-NH2 nanoparticles were then modified with poly(ethylene glycol) (PEG) via reaction with its succinimidyl ester yielding Fe3O4&SiO2-PEG particles. The in vitro biocompatibility and biosafety of the Fe3O4&SiO2 and Fe3O4&SiO2-PEG particles were investigated in a murine neural stem cell model in terms of oxidative stress response and cell viability, proliferation, and uptake. Finally, the potential of both nanoparticle types for application in magnetic resonance imaging (MRI) visualization was evaluated.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

RSC Advances

ISSN

2046-2069

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

15

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

8786-8797

UT code for WoS article

000393759900007

EID of the result in the Scopus database

2-s2.0-85011022704