Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00478611" target="_blank" >RIV/61389013:_____/17:00478611 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/17:00478611 RIV/61388971:_____/17:00478611 RIV/68378050:_____/17:00478611 RIV/00216208:11110/17:10364673 RIV/00023001:_____/17:00076182

Result on the web

<a href="http://dx.doi.org/10.1039/C7RA08712H" target="_blank" >http://dx.doi.org/10.1039/C7RA08712H</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C7RA08712H" target="_blank" >10.1039/C7RA08712H</a>

Result language

angličtina

Original language name

Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models

Original language description

Nanoparticles are constructs that can be used for cellular interventions and targeted drug delivery. They are useful for overcoming the dose-related toxic effects of drugs or diagnostic preparations by predominant or selective accumulation in the pathologic tissues. Gadolinium(III) compounds are largely used as contrast agents in magnetic resonance imaging but may have toxic effects, especially in nephropathic patients, due to the dose required for use in MRI. Here, we describe the preparation of new multifunctional NaGdF4:Yb3+/Er3+ nanoparticles, their characteristic properties, and some preliminary data about their effect on cell viability and tissue localization. Hexagonal-phase NaGdF4 nanocrystals that were doped with optically active Yb3+ and Er3+ ions, were synthesized by coprecipitation of lanthanide chlorides in octadec-1-ene at high temperature, stabilized by oleic acid, and subsequently coated with a thin silica layer. The morphology, elemental composition, crystalline structure, and SiO2 coating of the prepared NaGdF4:Yb3+/Er3+@SiO2 nanoparticles were characterized in detail by transmission electron microscopy combined with energy-dispersive spectroscopy and selected area electron diffraction and attenuated total reflection Fourier transform infrared (ATR FTIR) spectroscopy. The upconversion and paramagnetic properties of the particles were measured using confocal microscopy and MRI, respectively. The biocompatibility of the NaGdF4:Yb3+/Er3+@SiO2 nanoparticles was tested in vitro using mouse 3T3 fibroblasts and B16F10 melanoma cells. Particle localization was evaluated ex vivo in tumor, liver, and brain tissues of B16F10 melanoma bearing mice after intravenous administration. The NaGdF4:Yb3+/Er3+@SiO2 particles proved to be non-toxic at moderate concentrations. Particle localization within the organs was demonstrated by analysis of the tissues using laser ablation inductively coupled plasma mass spectrometry and showed vascular localization.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

RSC Advances

ISSN

2046-2069

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

73

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

45997-46006

UT code for WoS article

000412211300014

EID of the result in the Scopus database

2-s2.0-85030655552