Comparison of carboxybetaine with sulfobetaine polyaspartamides: Nonfouling properties, hydrophilicity, cytotoxicity and model nanogelation in an inverse miniemulsion
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00555583" target="_blank" >RIV/61389013:_____/22:00555583 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10446618
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/app.52099" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/app.52099</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/app.52099" target="_blank" >10.1002/app.52099</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of carboxybetaine with sulfobetaine polyaspartamides: Nonfouling properties, hydrophilicity, cytotoxicity and model nanogelation in an inverse miniemulsion
Original language description
Zwitterionic polymers are promising non-fouling materials widely used for surface modification. Here, we report the synthesis of zwitterionic polyaspartamides bearing carboxybetaine and sulfobetaine prepared via combining the ring-opening reaction of polysuccinimide with 3-(dimethylamino)-1-propylamine and the reaction of the formed tertiary amine side groups with 1,3-propanesultone and 4-bromobutyric acid, respectively. Both sulfobetaine and carboxybetaine polyaspartamides have cationic and anionic charged groups on the same repeat unit, but they differ in negatively charged groups. The chemical structures of the synthesized polymers were confirmed by 1H NMR and FT-IR spectroscopies. The zwitterionic property of polyaspartamides were characterized by zeta potential measurements using wide range of pH. The surface properties mainly anti-protein adsorption abilities and hydrophilicity were tested by surface plasmon resonance analysis, fluorescence microscopy, and contact angle measurements. Importantly, sulfobetaine polyaspartamides demonstrated better both antifouling performance and ability to form more hydrophilic surfaces than carboxybetaine polyaspartamide. Two zwitterionic carboxybetaine and sulfobetaine nanogels were prepared by horseradish peroxidase-mediated crosslinking in an inverse miniemulsion. Results from dynamic light scattering and transmission electron microscopy showed the formation of nanosized spherical particles. Additionally, sulfobetaine and carboxybetaine polyaspartamides had remarkable biocompatibilities, indicating their promise as non-fouling materials for biomedical applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA21-06524S" target="_blank" >GA21-06524S: Xeno-free enzymatically degradable polymer materials for 4D bioprinting</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Applied Polymer Science
ISSN
0021-8995
e-ISSN
1097-4628
Volume of the periodical
139
Issue of the periodical within the volume
19
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
e52099
UT code for WoS article
000736089600001
EID of the result in the Scopus database
2-s2.0-85122062038