Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00573142" target="_blank" >RIV/61389013:_____/23:00573142 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s13233-023-00145-6" target="_blank" >https://link.springer.com/article/10.1007/s13233-023-00145-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13233-023-00145-6" target="_blank" >10.1007/s13233-023-00145-6</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)
Original language description
Zwitterionic polymers are frequently used as non-fouling materials for surface modification with following application in medical devices, implants or areas of our lives such as food, water, and energy. Here, authors report the synthesis of zwitterionic poly(l-glutamic acid) copolymer bearing sulfobetaine via combining the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-l-glutamate and grafting reaction of propargylamine, tyramine, and 3-(dimethylamino)-1-propylamine to the polymer backbone with subsequent reaction of 1,3-propanesultone leading to the formation of zwitterionic poly(l-glutamic acid) containing sulfobetaine groups. Zwitterionic properties of the copolymer are represented by positively charged quaternary ammonium groups and negatively charged sulfobetaine moieties. The chemical structure of the synthesized zwitterionic poly(l-glutamic acid) was characterized by 1H NMR, FTIR, and UV/Vis spectroscopy. The zwitterionic abilities of copolymer were confirmed by zeta potential measurements. The zeta potential of zwitterionic polymer decreased from + 15 mV to − 19 mV upon stepwise pH increases from 2 to 11. The surface properties such as hydrophilicity and non-fouling abilities were tested by contact angle analysis and surface plasmon resonance technique, respectively. The prepared material indicates the formation of highly hydrophilic surfaces with relatively low contact angle (26°) and remarkable anti-protein adsorption functions reflected in lower resonance wavelength shifts from SPR sensogram. Results of this work show the importance of the developed biodegradable zwitterionic poly(l-glutamic acid)-based coatings for applications in various biomedical fields.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA21-06524S" target="_blank" >GA21-06524S: Xeno-free enzymatically degradable polymer materials for 4D bioprinting</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Research
ISSN
1598-5032
e-ISSN
2092-7673
Volume of the periodical
31
Issue of the periodical within the volume
6
Country of publishing house
KR - KOREA, REPUBLIC OF
Number of pages
9
Pages from-to
593-601
UT code for WoS article
000944096700001
EID of the result in the Scopus database
2-s2.0-85149290139