Zwitterionic polyaspartamides based on L-lysine side-chain moieties: synthesis, nonfouling properties and direct/indirect nanogel preparation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00540931" target="_blank" >RIV/61389013:_____/21:00540931 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/21:10430571

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0014305721000811?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305721000811?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2021.110347" target="_blank" >10.1016/j.eurpolymj.2021.110347</a>

Result language

angličtina

Original language name

Zwitterionic polyaspartamides based on L-lysine side-chain moieties: synthesis, nonfouling properties and direct/indirect nanogel preparation

Original language description

The ability of polysuccinimide (PSI) to open the succinimide ring by nucleophilic reagents leads to the formation of various polyaspartamides under mild conditions. In the current work, amino acids, such as Nα-Boc-L-lysine, leading to the formation of exclusively α-substituted L-lysine polypeptides and L-lysine methyl ester were used as the ring-opening reagents for PSI. The formed materials possess both positively and negatively charged groups on the same repeat unit simultaneously serving as zwitterionic moieties. The chemical structure and component composition were confirmed by 1H NMR and UV/vis spectroscopies. Zwitterionic properties of the synthesized polymers were investigated by zeta potential measurements. The obtained zwitterionic polyaspartamides exhibited anti-protein adsorption properties and the ability to create hydrophilic surfaces. The zwitterionic polyaspartamide nanogels obtained by horseradish peroxidase-mediated crosslinking in inverse miniemulsions and applying different preparation strategies were analysed by dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) analysis. The results indicated the good morphology and architecture of the nanogels. These peptide-based zwitterionic nanogels, due to their good biocompatibility and anti-protein adsorption ability, are promising materials for biomedical applications.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

<a href="/en/project/GA18-03224S" target="_blank" >GA18-03224S: INJECTABLE POLYPEPTIDE BASED HYDROGELS MIMICKING THE DYNAMIC PROCESSES IN EXTRACELLULAR MATRIX</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Polymer Journal

ISSN

0014-3057

e-ISSN

1873-1945

Volume of the periodical

148

Issue of the periodical within the volume

5 April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

110347

UT code for WoS article

000639291300002

EID of the result in the Scopus database

2-s2.0-85101500212