pH-Dependent disruption of giant polymer vesicles: a step towards biomimetic membranes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00567447" target="_blank" >RIV/61389013:_____/23:00567447 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2023/PY/D2PY01229D" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2023/PY/D2PY01229D</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D2PY01229D" target="_blank" >10.1039/D2PY01229D</a>
Alternative languages
Result language
angličtina
Original language name
pH-Dependent disruption of giant polymer vesicles: a step towards biomimetic membranes
Original language description
Giant unilamellar polymer vesicles (GUPVs) capable of selectively delivering protected payloads into intracellular environments and releasing them in stimuli-triggered, precise spatially and temporally controlled manners are attractive bioactive cargo delivery tools. Herein, we present highly size-defined and monodisperse (42.1 ± 1.2, 60.5 ± 1.0, 80.4 ± 1.4 and 97.9 ± 1.2 μm in diameter, respectively) pH-responsive giant GUPVs prepared via microfluidic droplet generation using a flow-focusing poly(dimethylsiloxane) (PDMS)-based microfluidic device. Poly(ethylene oxide)-block-poly[2-(diisopropylamino)ethyl methacrylate] (PEO-b-PDPA) is a pH-responsive polymer that was synthesized via reversible addition–fragmentation chain-transfer (RAFT) polymerization and used in combination with poly(ethylene oxide)-block-poly(1,2-butadiene) (PEO-b-PBD) to produce homogeneous pH-responsive giant GUPVs. To demonstrate the spatiotemporal control provided by this approach, we studied in detail the pH-responsiveness of GUPVs according to the disruption and release of dye cargo under distinct acidic conditions using fluorescence confocal microscopy. This approach can be utilized to fabricate pH-responsive delivery systems for various active compounds, microreactors, and artificial organelles, thereby paving the way towards cell mimicry.n
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer Chemistry
ISSN
1759-9954
e-ISSN
1759-9962
Volume of the periodical
14
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
443-451
UT code for WoS article
000899359800001
EID of the result in the Scopus database
2-s2.0-85144786973