Thioether-based poly(2-oxazoline)s: from optimized synthesis to advanced ROS-responsive nanomaterials

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00577520" target="_blank" >RIV/61389013:_____/23:00577520 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/23:10471049

Result on the web

<a href="https://pubs.rsc.org/en/content/articlelanding/2023/PY/D3PY00945A" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2023/PY/D3PY00945A</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/D3PY00945A" target="_blank" >10.1039/D3PY00945A</a>

Result language

angličtina

Original language name

Thioether-based poly(2-oxazoline)s: from optimized synthesis to advanced ROS-responsive nanomaterials

Original language description

Intelligent redox-responsive polymers, such as thioether-containing macromolecules, facilitate drug delivery and triggered release in biomedical applications. Moreover, reactive oxygen species (ROS)-responsive thioether systems based on poly(2-oxazoline)s (PAOx) platforms hold great promise for the development of highly biocompatible, stimuli-responsive biomaterials. However, thioether-containing PAOx are particularly difficult to synthesize because thioethers are incompatible with the cationic ring-opening polymerization (CROP). In this study, we aim at developing an alternative route to well-defined thioether-containing PAOx by a simple post-polymerization modification of linear polyethyleneimine. First, the synthesis of ROS-responsive PAOx homopolymers was optimized. Furthermore, ROS-sensitive amphiphilic diblock copolymers poly(ethylene glycol)-block-poly(2-methylthiomethyl-2-oxazoline) were synthesized by combining CROP with 2-oxazoline side-chain interchange via a polyethyleneimine block intermediate. In an aqueous environment, the copolymers self-assembled into thioether-containing micelles. These micelles were characterized by size exclusion chromatography, nuclear magnetic resonance, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, dynamic light scattering, differential scanning calorimetry, and transmission electron microscopy. In addition, treatment with diluted H2O2 destabilized the nanoparticles, thus demonstrating their oxidation-responsiveness. This approach provides key insights into the design and development of stimuli-responsive polymers for potential biomedical applications, such as drug delivery systems.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymer Chemistry

ISSN

1759-9954

e-ISSN

1759-9962

Volume of the periodical

14

Issue of the periodical within the volume

42

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

4838-4847

UT code for WoS article

001085531400001

EID of the result in the Scopus database

2-s2.0-85175237285