Well-defined poly(2-isopropenyl-2-oxazoline) brushes provide fouling resistance and versatility in surface functionalization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00588486" target="_blank" >RIV/61389013:_____/24:00588486 - isvavai.cz</a>

Result on the web

<a href="https://pubs.rsc.org/en/content/articlelanding/2024/py/d4py00424h" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/py/d4py00424h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/D4PY00424H" target="_blank" >10.1039/D4PY00424H</a>

Result language

angličtina

Original language name

Well-defined poly(2-isopropenyl-2-oxazoline) brushes provide fouling resistance and versatility in surface functionalization

Original language description

Poly(2-isopropenyl-2-oxazoline) (PIPOx), a biocompatible polymer amenable to clean and orthogonal post-polymerization modifications, has recently emerged as a suitable candidate for the preparation of functional polymer brushes via surface-initiated reversible-deactivation radical polymerization (SI RDRP). However, the field currently lacks a universal SI RDRP method that would provide a straightforward control over the PIPOx brush thickness and be applicable to non-planar surfaces. Herein, we designed an aqueous, metallic copper-mediated RDRP (Cu(0)-RDRP) protocol for SI grafting of IPOx that manifests an excellent degree of temporal control over the PIPOx brush thickness up to more than 100 nm. The superior kinetic control was achieved through the use of an all-chlorine initiation/catalytic Cu(0)-RDRP system and careful ligand selection, demonstrating a clear advantage over previous approaches based on brominated initiators. Additionally, we found that using neat water as a reaction medium for the Cu(0) catalyst generation in the standard disproportionation step significantly accelerates the brush growth. Importantly, a surface plasmon resonance analysis demonstrated for the first time the high resistance of PIPOx brushes against non-specific protein fouling, as documented by a significant (96%) decrease in protein deposition from undiluted blood plasma and negligible adsorption from fetal bovine serum and other protein solutions. Finally, we showcased in model scenarios the versatility of the prepared well-defined PIPOx brushes by modifying them with suitable functional carboxylic acids under mild conditions in order to subsequently synthesize graft copolymer brushes or trigger a CuAAC click reaction. Our results highlight PIPOx brushes as an attractive platform for the fabrication of low-fouling, multifunctional surfaces.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymer Chemistry

ISSN

1759-9954

e-ISSN

1759-9962

Volume of the periodical

15

Issue of the periodical within the volume

32

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

3300-3310

UT code for WoS article

001279745100001

EID of the result in the Scopus database

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