Hyaluronic acid nanoparticles with parameters required for in vivo applications: from synthesis to parametrization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00588498" target="_blank" >RIV/61389013:_____/24:00588498 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/25:00563507 RIV/00216224:14310/24:00136928 RIV/00216275:25310/24:39921556
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.4c00370" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.4c00370</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.4c00370" target="_blank" >10.1021/acs.biomac.4c00370</a>
Alternative languages
Result language
angličtina
Original language name
Hyaluronic acid nanoparticles with parameters required for in vivo applications: from synthesis to parametrization
Original language description
Hyaluronic acid is an excellent biocompatible material for in vivo applications. Its ability to bind CD44, a cell receptor involved in numerous biological processes, predetermines HA-based nanomaterials as unique carrier for therapeutic and theranostic applications. Although numerous methods for the synthesis of hyaluronic acid nanoparticles (HANPs) are available today, their low reproducibility and wide size distribution hinder the precise assessment of the effect on the organism. A robust and reproducible approach for producing HANPs that meet strict criteria for in vivo applications (e.g., to lung parenchyma) remains challenging. We designed and evaluated four protocols for the preparation of HANPs with those required parameters. The HA molecule was cross-linked by novel combinations of carbodiimide, and four different amine-containing compounds resulted in monodisperse HANPs with a low polydispersity index. By a complex postsynthetic characterization, we confirmed that the prepared HANPs meet the criteria for inhaled therapeutic delivery and other in vivo applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomacromolecules
ISSN
1525-7797
e-ISSN
1526-4602
Volume of the periodical
25
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
4934-4945
UT code for WoS article
001259876300001
EID of the result in the Scopus database
2-s2.0-85197055342