Single-step synthesis of highly sensitive 19F MRI tracers by gradient copolymerization-induced self-assembly

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00602494" target="_blank" >RIV/61389013:_____/24:00602494 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10487827 RIV/00023001:_____/24:00085255 RIV/46747885:24530/24:00013298 RIV/00216208:11110/24:10487827 RIV/00216208:11120/24:43927752
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.4c00915" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.4c00915</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.4c00915" target="_blank" >10.1021/acs.biomac.4c00915</a>

Result language
angličtina
Original language name
Single-step synthesis of highly sensitive 19F MRI tracers by gradient copolymerization-induced self-assembly
Original language description
Amphiphilic gradient copolymers are promising alternatives to block copolymers for self-assembled nanomaterials due to their straightforward synthesis via statistical copolymerization of monomers with different reactivities and hydrophilicity. By carefully selecting monomers, nanoparticles can be synthesized in a single step through gradient copolymerization-induced self-assembly (gPISA). We synthesized highly sensitive 19F MRI nanotracers via aqueous dispersion gPISA of hydrophilic poly(ethylene glycol) methyl ether methacrylate (PEGMA) with core-forming N,N-(2,2,2-trifluoroethyl)acrylamide (TFEAM). The PPEGMA-grad-PTFEAM nanoparticles were optimized to achieve spherical morphology and exceptional 19F MRI performance. Noncytotoxicity was confirmed in Panc-1 cells. In vitro 19F MR relaxometry and imaging demonstrated their diagnostic imaging potential. Notably, these gradient copolymer nanotracers outperformed block copolymer analogs in 19F MRI performance due to their gradient architecture, enhancing 19F relaxivity. The synthetic versatility and superior 19F MRI performance of gradient copolymers highlight their potential in advanced diagnostic imaging applications.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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