Non-destructive in vivo tracking of gelatin hydrogels for advancing tissue engineering

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00636587" target="_blank" >RIV/61389013:_____/25:00636587 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10499915
Result on the web
<a href="https://www.nature.com/articles/s43246-025-00830-2" target="_blank" >https://www.nature.com/articles/s43246-025-00830-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s43246-025-00830-2" target="_blank" >10.1038/s43246-025-00830-2</a>

Result language
angličtina
Original language name
Non-destructive in vivo tracking of gelatin hydrogels for advancing tissue engineering
Original language description
Photo-crosslinkable gelatin-based hydrogels hold great promise for tissue engineering and regenerative medicine. However, monitoring these hydrogels in vivo remains challenging and limits their further development and clinical translation. Here, we address this limitation by utilizing a gelatin-based hydrogel that incorporates the radiopaque compound 5-acrylamido-2,4,6-triiodoisophthalic acid (AATIPA). In an in vivo study spanning over 400 days, we monitor the degradation kinetics of these hydrogels using computed tomography and ultrasonography. We synthesize three distinct AATIPA-containing hydrogels and implant them subcutaneously into mice. Hydrogels with high crosslink density show minimal degradation, while those with lower crosslinking densities degrade within approximately three months. Histological evaluation reveals that the scaffolds are replaced by adjacent adipose tissue. In vitro, adipose-derived stem cells differentiate into the adipogenic lineage, corroborating the in vivo findings. These results highlight the potential of these hydrogels for adipose tissue engineering by enabling in vivo monitoring and offering tailored degradation profiles.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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