Photoprintable Radiopaque Hydrogels for Regenerative Medicine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00583453" target="_blank" >RIV/61388963:_____/24:00583453 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10483467
Result on the web
<a href="https://doi.org/10.1021/acsaenm.3c00533" target="_blank" >https://doi.org/10.1021/acsaenm.3c00533</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsaenm.3c00533" target="_blank" >10.1021/acsaenm.3c00533</a>
Alternative languages
Result language
angličtina
Original language name
Photoprintable Radiopaque Hydrogels for Regenerative Medicine
Original language description
Biodegradable and bioactive gelatin-based hydrogels improve tissue regeneration and wound healing by supporting cell proliferation. Suitably functionalized gelatin hydrogels can even be processed by light-based 3D printing into any required shape, and their physicochemical and biological properties can be modified by incorporating various comonomers into their structure. However, such hydrogels are difficult to monitor in vivo, which has hampered further developments and clinical translation. Herein, we prepared gelatin-based hydrogels with radiopacity by incorporation with biocompatible and radiopaque comonomer 5-acrylamido-2,4,6-triiodoisophthalic acid (AATIPA) and processing through light-based additive manufacturing. Our results showed that adding AATIPA to the reaction mixture significantly accelerates light-induced cross-linking and improves the storage modulus (G′) and swelling ratio (SR) of the cross-linked hydrogels, providing them with radiopacity for in vivo monitoring by X-ray and computed tomography (CT). Because these AATIPA-containing gelatin-based hydrogels are noncytotoxic and support cell proliferation, they offer a cost-effective and versatile, 3D-printable platform with tunable radiopacity for biomedical applications. Therefore, our findings pave the way toward the clinical translation of photo-cross-linked 3D-printed hydrogels into tissue engineering and regenerative medicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LTC20076" target="_blank" >LTC20076: Impact of Photoinduced Charge Migration on Photochemistry of Radicals and Switches</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Applied Engineering Materials
ISSN
2771-9545
e-ISSN
2771-9545
Volume of the periodical
2
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
811-817
UT code for WoS article
001289344600001
EID of the result in the Scopus database
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