Development of maleimide-modified poly(N-(2-hydroxylpropyl)methacrylamide) as a novel mucoadhesive polymer for nasal drug delivery

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00638337" target="_blank" >RIV/61389013:_____/25:00638337 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0014305725004811?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305725004811?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2025.114193" target="_blank" >10.1016/j.eurpolymj.2025.114193</a>

Result language
angličtina
Original language name
Development of maleimide-modified poly(N-(2-hydroxylpropyl)methacrylamide) as a novel mucoadhesive polymer for nasal drug delivery
Original language description
Nasal drug administration is an attractive option for systemic drug delivery, but it is often limited by inadequate nasal drug absorption. In this study, we investigated novel mucoadhesive poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA)-based copolymers functionalised with maleimide moieties as formulations to enhance the retention of dosage forms on the nasal mucosa. PHPMA and its maleimide derivatives were synthesised using controlled radical polymerisation, resulting in polymers with well-defined structures, low dispersity, and variable maleimide functionality. Functionalisation of PHPMA with maleimide groups substantially improved its mucoadhesive properties. Importantly, copolymers with low maleimide content, which were nevertheless sufficient for mucoadhesion, showed no significant cytotoxicity against HEK293 cells and no mucosal irritation in a slug mucosal irritation assay. These PHPMA derivatives demonstrate excellent potential as mucoadhesive materials for developing dosage forms for nasal drug delivery.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
<a href="/en/project/GA22-12483S" target="_blank" >GA22-12483S: Polymer-based drug delivery vectors targeting stemness and metabolism of glioblastoma cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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