Synthesis of morphologically diverse dual thermo- and pH-responsive nano-objects via RAFT-mediated emulsion PISA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00641357" target="_blank" >RIV/61389013:_____/25:00641357 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2025/na/d5na00779h" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/na/d5na00779h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D5NA00779H" target="_blank" >10.1039/D5NA00779H</a>

Result language
angličtina
Original language name
Synthesis of morphologically diverse dual thermo- and pH-responsive nano-objects via RAFT-mediated emulsion PISA
Original language description
We report a versatile and efficient strategy for the synthesis of dual thermo- and pH-responsive polymeric nano-objects with rich morphological diversity, achieved via RAFT-mediated aqueous emulsion polymerization-induced self-assembly (PISA). Using a thermoresponsive poly(triethylene glycol methyl ether methacrylate) (PTEGMA) macro-chain transfer agent and a pH-sensitive diisopropylaminoethyl methacrylate (DPA) monomer, we generated PTEGMA-b-PDPA diblock copolymer nano-objects under conditions both below and above the LCST of PTEGMA. By systematically varying the length of the PDPA block, we accessed a wide array of morphologies—including micelles, worms, vesicles, and intricate “octopus”-like structures—simply by adjusting the polymerization temperature and hydrophobic block length. These nanostructures displayed clear dual responsiveness: thermally triggered aggregation around ∼40 °C and reversible disassembly in acidic environments. Our findings highlight the precise morphological control achievable through aqueous RAFT-PISA and underscore its potential for designing smart nanomaterials tailored for biomedical and stimuli-responsive applications.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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