Enzymatic etching of PLA/hydroxyapatite scaffolds for improved cell adhesion: surface modification and homogeneity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00646595" target="_blank" >RIV/61389013:_____/25:00646595 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s42247-025-01087-8" target="_blank" >https://link.springer.com/article/10.1007/s42247-025-01087-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s42247-025-01087-8" target="_blank" >10.1007/s42247-025-01087-8</a>
Alternative languages
Result language
angličtina
Original language name
Enzymatic etching of PLA/hydroxyapatite scaffolds for improved cell adhesion: surface modification and homogeneity
Original language description
Nanosized hydroxyapatite (HAP) particles were produced by precipitation, and poly(lactic acid) (PLA) composites containing 5 wt% of the nano HAP were prepared in an internal mixer to prepare scaffold materials. The nanoparticles aggregated without surface modification. Applying stearic acid coating on HAP particles decreased aggregation and improved homogeneity. The extent of coating must be optimized, the amount of stearic acid needed for monolayer coverage is around 4 wt% for the HAP prepared. A polymer layer always forms on the surface of PLA products during the melt processing of PLA/HAP composites, HAP particles are not available to help bone regeneration. The surface layer was removed successfully by enzymatic etching. The amount of removed PLA polymer depended quite strongly on the extent of surface coating. Etching disclosed the HAP particles, which led to increased surface roughness and decreased wettability, but this did not influence the adhesion of cells on the surface. Scaffolds could be prepared successfully by 3D printing from the composites containing the coated particles, which, in all probability, can be successfully used for bone regeneration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Emergent Materials
ISSN
2522-5731
e-ISSN
2522-574X
Volume of the periodical
8
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
6509-6521
UT code for WoS article
001471144400001
EID of the result in the Scopus database
2-s2.0-105003141241