Preparation and cytotoxic activity of nickel(II) complexes with 6-benzylaminopurine derivatives.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F02%3A56023063" target="_blank" >RIV/61389030:_____/02:56023063 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Preparation and cytotoxic activity of nickel(II) complexes with 6-benzylaminopurine derivatives.

Original language description

Nickel(II) complexes with 6-benzylaminopurine (BAP) derivatives, namely 6-(3-chlorobenzylamino) purine (HL1), 6-4-chlorobenzylamino) purine (HL2) and 6-(4-fluorobenzylamino) purine (HL3), have been prepared and characterized by elemental analyses, i.r.,u.v.-v.i.s., ES+ and FAB+ mass spectroscopy, magnetic susceptibility and conductivity measurements, and by thermal analysis. The complexes are: [Ni(L-1(H2O)(2)Cl].H2O, [Ni(L-1)(H2O)(NO3)].H2O, [Ni(L-2)(H2O)(2)Cl], [Ni(L-2)(H2O)(2)(NO3)].H2O, [Ni(HL2)(H2O)Cl-2].EtOH and [Ni(L-3)(H2O)(2)Cl]. They have been tested in vitro for their possible cytotoxic activity against G-361 ( human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 ( human breast adenocarcinoma) cell lines.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transition Metal Chemistry

ISSN

0340-4285

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

8

Country of publishing house

AT - AUSTRIA

Number of pages

6

Pages from-to

918-923

UT code for WoS article

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EID of the result in the Scopus database

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