Synthesis, characterization and in vitro cytotoxicity of Co(II) complexes with N6-substituted adenine derivates: X-ray structures of 6-(4-chlorobenzylamino)purin-di-ium diperchlorate dihydrate and [Co-6(mu-L-6)(4)Cl-8(DMSO)(10)].4DMSO

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F06%3A00002612" target="_blank" >RIV/61989592:15310/06:00002612 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Synthesis, characterization and in vitro cytotoxicity of Co(II) complexes with N6-substituted adenine derivates: X-ray structures of 6-(4-chlorobenzylamino)purin-di-ium diperchlorate dihydrate and [Co-6(mu-L-6)(4)Cl-8(DMSO)(10)].4DMSO

Original language description

Cobalt(II) complexes of the composition [Co(L-1)Cl(H2O)(2)].H2O (1), [Co(L-2)Cl(H2O)(2)].2H2O (2), [Co(L-3)Cl(H2O)(2)].H2O (3), [Co(L-4)Cl(H2O)(2)].H2O (4), [Co(L-5)Cl(H2O)(2)].H2O (5) and [Co(L-6)Cl(H2O)(2)] (6), where HL1 = 6-(3-chlorobenzylamino)purine, HL2 = 6-(4-chlorobenzylamino)purine, HL3 = 6-(2,3-dimethoxybenzylamino)purine, HL4 = 6-(3,4-dimethoxybenzylamino)purine, HL5 = 6-(3-fluorobenzylamino)purine and HL6 = 6-(4-fluorobenazylamino)purine, have been prepared. The compounds have been characterized by elemental analyses, ES+ mass, UV-Vis, IR and NMR spectroscopies, magnetic measurements, molar conductances and thermogravimetric analysis as mononuclear tetrahedral high-spin cobalt(II) complexes. In vitro cytotoxicities of the complexes were tested by a Calcein AM assay against the following human tumour cell lines: malignant melanoma (G361), chronic adenocarcinoma (MCF7). The molecular strucures of 6-(4-chlorobenzylamino)purin-di-ium diperchlorate dihydrate, [H2+L-2](ClO4)(2).

Czech name

Příprava, charakterizace a in vitro cytotoxicita Co(II) komplexů s N6-substituovanými deriváty adeninu: rentgenostrukturní analýza dihydrátu chloristanu 6-(4-chlorobenzylamino)purin-di-ia a [Co-6(mu-L-6)(4)Cl-8(DMSO)(10)].4DMSO

Czech description

Co(II) komplexy o složení [Co(L-1)Cl(H2O)(2)].H2O (1), [Co(L-2)Cl(H2O)(2)].2H2O (2), [Co(L-3)Cl(H2O)(2)].H2O (3), [Co(L-4)Cl(H2O)(2)].H2O (4), [Co(L-5)Cl(H2O)(2)].H2O (5) and [Co(L-6)Cl(H2O)(2)] (6), kde HL1 = 6-(3-chlorobenzylamino)purin, HL2 = 6-(4-chlorobenzylamino)purin, HL3 = 6-(2,3-dimethoxybenzylamino)purin, HL4 = 6-(3,4-dimethoxybenzylamino)purin, HL5 = 6-(3-fluorobenzylamino)purin and HL6 = 6-(4-fluorobenazylamino)purin, byly připraveny. Sloučeniny byly charakterizovány pomocí elementární analýzy, ES+MS, UV-Vis, IR a NMR spektroskopie, magnetických měření, molárních vodivostí a TG analýzy jako jednojaderné tetraedrické vysoko-spinové Co(II) komplexy. In vitro cytotoxicita komplexů byla testována na následujících lidských tumorovývh liniích: maligní melanom (G361), chronický adenocarcinom (MCF7). Molekulové struktury dihydrátu chloristanu 6-(4-chlorobenzylamino)purin-di-ia [H2+L-2](ClO4)(2).2H2O, a šestijaderného Co(II) komplexu, [Co-6(mu-L-6)(4)Cl-8(DMSO)(10)].4DMSO (7), byla

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

—

Project

<a href="/en/project/GA203%2F04%2F1168" target="_blank" >GA203/04/1168: Complexes of selected transition metals with cytokinin derivatives: synthesis, characterization and biological activity</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polyhedron

ISSN

0277-5387

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

1421-1432

UT code for WoS article

—

EID of the result in the Scopus database

—