Gene Silencing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F10%3A00375430" target="_blank" >RIV/61389030:_____/10:00375430 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-90-481-2967-6_27" target="_blank" >http://dx.doi.org/10.1007/978-90-481-2967-6_27</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-90-481-2967-6_27" target="_blank" >10.1007/978-90-481-2967-6_27</a>

Result language
angličtina
Original language name
Gene Silencing
Original language description
By 1998, it was recognized both in animal and plant systems that rearrangements of the transgene that allowed anti-parallel RNA strands to be generated stimulated a templated degradation system (RISC complex) that includes specific small RNAs together with Argonaute proteins and Dicer-like proteins that cleave the targeted RNA into characteristic 21?25 nt degradation products. In addition to induction by anti-parallel RNAs, RNAi degradation systems can be induced by virus replication intermediates as innatural host defense mechanisms. By 2001, another kind of small RNA involved in regulation of gene expression was discovered and termed microRNA. These endogenous 21 nt small RNAs play several roles in gene regulatory networks and often target other regulatory genes. Artificial small RNAs can also be designed to inactivate target genes to generate the mutant phenotypes which are useful for crop improvement.
Czech name
—
Czech description
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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