Young Barley Indicates Antitumor Effects in Experimental Breast Cancer In Vivo and In Vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F16%3A00461726" target="_blank" >RIV/61389030:_____/16:00461726 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/16:72306 RIV/62157124:16370/16:43874498

Result on the web

<a href="http://dx.doi.org/10.1080/01635581.2016.1154577" target="_blank" >http://dx.doi.org/10.1080/01635581.2016.1154577</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/01635581.2016.1154577" target="_blank" >10.1080/01635581.2016.1154577</a>

Result language

angličtina

Original language name

Young Barley Indicates Antitumor Effects in Experimental Breast Cancer In Vivo and In Vitro

Original language description

The effect of dietary administered young barley containing a mixture of phytochemicals to female rats for the prevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis was evaluated. After carcinogen administration (14 wk), mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. Moreover, in vitro evaluation of possible mechanisms in MCF-7 breast cancer cell line was performed. Barley (0.3%) demonstrated mild antitumor effect in mammary carcinogenesis, yet 3% barley did not further improve this effect. Immunohistochemical analysis of rat tumor cells in treated groups showed significant increase in caspase-3 expression and significant reduction in Ki67 expression. In addition, 3% barley significantly decreased dityrosine levels versus control. Barley in higher dose significantly decreased serum low-density lipoprotein-cholesterol in rats. In vitro studies showed that barley significantly decreased survival of MCF-7 cells in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and significantly decreased 5-bromo-20-deoxyuridine incorporation versus control. Barley prevented cell cycle progression and extended incubation with barley showed significant increase in the percentage of annexin V/propidium iodide-positive MCF-7 cells. Our results propose an antitumor effect for the mixture of phytochemicals present in young barley in a breast cancer model.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrition and Cancer-An International Journal

ISSN

0163-5581

e-ISSN

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Volume of the periodical

68

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

611-621

UT code for WoS article

000378171700009

EID of the result in the Scopus database

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