Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F16%3A00467237" target="_blank" >RIV/61389030:_____/16:00467237 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/16:00065585 RIV/00216224:14110/16:00091211 RIV/61989592:15310/16:33162443 RIV/00216275:25310/16:39901614

Result on the web

<a href="http://dx.doi.org/10.1016/j.tiv.2016.09.006" target="_blank" >http://dx.doi.org/10.1016/j.tiv.2016.09.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tiv.2016.09.006" target="_blank" >10.1016/j.tiv.2016.09.006</a>

Result language

angličtina

Original language name

Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux

Original language description

N-((R)-1-(4-chlorophenylcarbamoy1)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (Compound 6k), was recently isolated during the preparation of amino adds esters with salicylanilides. We show here that 6k disrupts the dynamics of actin cytoskeleton in human melanoma cells, affecting processes essential for the maintenance and expansion of tumours such as cell adlision, motility, proliferation, vesicular transport, and autophagic flux. We demonstrated that inhibition of autophagy by 6k increased the sensitivity of melanoma cells to metabolic stress induced by rotenone or nutrient starvation and potentiated the anti-proliferative activity of small molecule multikinase inhibitor sorafenib. Since autophagy plays an important role in survival of cancer cells subjected to chemotherapy, the above mentioned properties are interesting from clinical point of view as 6k could promote metabolic stress within the tumour microenvironment and potentiate the effect of cytostatics in combination therapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology in Vitro

ISSN

0887-2333

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

DEC

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

70-78

UT code for WoS article

000387198300009

EID of the result in the Scopus database

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