Synthesis and antiproliferative activities of novel O-benzyl salicylamide derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00476525" target="_blank" >RIV/61389030:_____/17:00476525 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/17:73583914 RIV/00216275:25310/17:39911000
Result on the web
<a href="http://dx.doi.org/10.2174/1570180813666161020113827" target="_blank" >http://dx.doi.org/10.2174/1570180813666161020113827</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1570180813666161020113827" target="_blank" >10.2174/1570180813666161020113827</a>

Result language
angličtina
Original language name
Synthesis and antiproliferative activities of novel O-benzyl salicylamide derivatives
Original language description
On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties. Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds. Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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