Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F18%3A00488707" target="_blank" >RIV/61389030:_____/18:00488707 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/18:73584172 RIV/61989592:15310/18:73584172
Result on the web
<a href="http://dx.doi.org/10.1007/s10522-017-9742-4" target="_blank" >http://dx.doi.org/10.1007/s10522-017-9742-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10522-017-9742-4" target="_blank" >10.1007/s10522-017-9742-4</a>

Result language
angličtina
Original language name
Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans
Original language description
Cytokinins are phytohormones that are involved in many processes in plants, including growth, differentiation and leaf senescence. However, they also have various activities in animals. For example, kinetin and trans-zeatin can reduce levels of several aging markers in human fibroblasts. Kinetin can also protect mice against oxidative and glyoxidative stress, and prolong fruit flies’ lifespan. Additionally, several cytokinins are currently used in cosmetics. To extend knowledge of the breadth of cytokinins’ activities, we examined effects of natural cytokinin bases on the model nematode Caenorhabditis elegans. We found that kinetin, para-topolin and meta-topolin prolonged the lifespan of C. elegans. Kinetin also protected the organism against oxidative and heat stress. Furthermore, our results suggest that presence of reactive oxygen species, but not DAF-16 (the main effector of the insulin/insulin-like growth factor signaling pathway), is required for the beneficial effects of kinetin. Ultra-high performance liquid chromatography-tandem mass spectrometric analysis showed that kinetin is unlikely to occur naturally in C. elegans, but the worm efficiently absorbs and metabolizes it into kinetin riboside and kinetin riboside-5′-monophosphate.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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