Molecular architecture of the endocytic TPLATE complex
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F21%3A00545616" target="_blank" >RIV/61389030:_____/21:00545616 - isvavai.cz</a>
Result on the web
<a href="http://doi.org/10.1126/sciadv.abe7999" target="_blank" >http://doi.org/10.1126/sciadv.abe7999</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.abe7999" target="_blank" >10.1126/sciadv.abe7999</a>
Alternative languages
Result language
angličtina
Original language name
Molecular architecture of the endocytic TPLATE complex
Original language description
Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as an endocytic regulator. Unlike other coatomer complexes, structural insight into TSET is lacking. Here, we reveal the molecular architecture of plant TSET [TPLATE complex (TPC)] using an integrative structural approach. We identify crucial roles for specific TSET subunits in complex assembly and membrane interaction. Our data therefore generate fresh insight into the differences between the hexameric TSET in Dictyostelium and the octameric TPC in plants. Structural elucidation of this ancient adaptor complex represents the missing piece in the coatomer puzzle and vastly advances our functional as well as evolutionary insight into the process of endocytosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GA19-21758S" target="_blank" >GA19-21758S: Good-Cop/Bad-Cop: Distinct roles of anionic phospholipids in plant endocytosis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Advances
ISSN
2375-2548
e-ISSN
2375-2548
Volume of the periodical
7
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
eabe7999
UT code for WoS article
000622481300035
EID of the result in the Scopus database
2-s2.0-85102035889