Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F23%3A00575713" target="_blank" >RIV/61389030:_____/23:00575713 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/23:73622977

Result on the web

<a href="https://doi.org/10.1016/j.sajb.2023.05.030" target="_blank" >https://doi.org/10.1016/j.sajb.2023.05.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sajb.2023.05.030" target="_blank" >10.1016/j.sajb.2023.05.030</a>

Result language

angličtina

Original language name

Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants

Original language description

Diabetes mellitus (DM) is a chronic metabolic dysfunction characterised by hyperglycaemia. It is strongly linked to oxidative stress. Post-meal elevation of blood glucose levels predisposes humans to Type 2 DM. Retardation of the digestive enzymes α-glucosidase and α-amylase is an efficient therapeutic approach to regulate hyperglycaemia. Many indigenous plants are commonly used in managing DM. However, most of these claims have not been verified scientifically. This study investigated eleven indigenous South African plants for their antioxidant and hypoglycaemic potentials. The phytochemical content (total phenolics, flavonoids and condensed tannins) was quantified colormetrically. The antioxidant potential of crude leaf extracts was evaluated against ferric-reducing antioxidant power (FRAP) and 1,1-Diphenyl-2-picrylhydrazyl (DPPH•). In vitro inhibition of digestive enzymes (α-amylase and α-glucosidase) by the extracts were used to evaluate their antidiabetic activities. Six of the plant species investigated, namely, Catha edulis, Combretum kraussii, Lippia javanica, Endostemon obtusifolius, Psidium guajava and Syzygium cordatum had significant concentrations of flavonoids, total phenolics and/or condensed tannins. These six plant species generally demonstrated significantly lower IC50 values than the positive controls (butylated hydroxyl-toluene (BHT) and acarbose) in the in vitro antioxidant and antidiabetic assays. These results support the use of some of the investigated traditional plants in DM management. The antidiabetic potential of E. obtusifolius, a relatively under-utilized plant, as well as C. kraussii and C. edulis were highlighted as promising species for further investigation as hypoglycaemic agents.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10611 - Plant sciences, botany

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

South African Journal of Botany

ISSN

0254-6299

e-ISSN

1727-9321

Volume of the periodical

159

Issue of the periodical within the volume

AUG

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

686-696

UT code for WoS article

001044967700001

EID of the result in the Scopus database

2-s2.0-85165054762