Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F24%3A00600473" target="_blank" >RIV/61389030:_____/24:00600473 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/24:73628743
Result on the web
<a href="https://doi.org/10.1126/science.adj4591" target="_blank" >https://doi.org/10.1126/science.adj4591</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.adj4591" target="_blank" >10.1126/science.adj4591</a>
Alternative languages
Result language
angličtina
Original language name
Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export
Original language description
Brassinosteroids are steroidal phytohormones that regulate plant development and physiology, including adaptation to environmental stresses. Brassinosteroids are synthesized in the cell interior but bind receptors at the cell surface, necessitating a yet to be identified export mechanism. Here, we show that a member of the ATP-binding cassette (ABC) transporter superfamily, ABCB19, functions as a brassinosteroid exporter. We present its structure in both the substrate-unbound and the brassinosteroid-bound states. Bioactive brassinosteroids are potent activators of ABCB19 ATP hydrolysis activity, and transport assays showed that ABCB19 transports brassinosteroids. In Arabidopsis thaliana, ABCB19 and its close homolog, ABCB1, positively regulate brassinosteroid responses. Our results uncover an elusive export mechanism for bioactive brassinosteroids that is tightly coordinated with brassinosteroid signaling.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
1095-9203
Volume of the periodical
383
Issue of the periodical within the volume
6689
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
eadj4591
UT code for WoS article
001252955200028
EID of the result in the Scopus database
2-s2.0-85188561130