Inhibitor of apoptosis proteins in human health and disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA200212U" target="_blank" >RIV/61988987:17110/19:A200212U - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/19:E0108118
Result on the web
<a href="https://www.nature.com/articles/s41435-019-0078-8" target="_blank" >https://www.nature.com/articles/s41435-019-0078-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41435-019-0078-8" target="_blank" >10.1038/s41435-019-0078-8</a>

Result language
angličtina
Original language name
Inhibitor of apoptosis proteins in human health and disease
Original language description
The inhibitor of apoptosis proteins (IAPs) are best known for their ability to regulate cell survival and death processes. However, in addition to cell death, IAPs also act as innate immune sensors and modulate multiple pathways, such as autophagy and cell division. Many of these IAP functions are non-redundant even though they are based on the same molecular mechanism of action. These distinct functions of IAPs derive from their capacity to target specific substrates for ubiquitination and/or proteolytic cleavage. The unique functions of IAPs also derives from their unique cellular localizations, cell type and tissue-specific expression patterns. The diverse roles of IAPs are reflected by the fact that in humans the IAP family comprises eight distinct members. Genetic evidence from human pathologies also attests to the non-redundant functions of the IAPs since very diverse diseases arise upon aberrant IAP expression. In this review, we give an overview of the known mechanisms of action of the various IAPs, and focus on their specific roles in mediating innate immunity. We also look at the distinct phenotypes related to the dysregulation of the IAPs, and the human pathologies associated with each human IAP.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
<a href="/en/project/GJ18-24070Y" target="_blank" >GJ18-24070Y: Dissecting the interplay of ubiquitination and phosphorylation in oncogenic MyD88 signalling for discovery of new therapeutic targets in lymphoma</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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