Accuracy of Colon Capsule Endoscopy for Colorectal Neoplasia Detection in Individuals Referred for a Screening Colonoscopy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA210272U" target="_blank" >RIV/61988987:17110/19:A210272U - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10396706 RIV/00179906:_____/19:10396706 RIV/00023001:_____/19:00078367 RIV/00216224:14110/19:00108525 and 2 more

Result on the web

<a href="https://downloads.hindawi.com/journals/grp/2019/5975438.pdf" target="_blank" >https://downloads.hindawi.com/journals/grp/2019/5975438.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2019/5975438" target="_blank" >10.1155/2019/5975438</a>

Result language

angličtina

Original language name

Accuracy of Colon Capsule Endoscopy for Colorectal Neoplasia Detection in Individuals Referred for a Screening Colonoscopy

Original language description

Backround. Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim. To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods. From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method's characteristics (accuracy) and safety and patient acceptance of the routine. Enrolled participants fulfilled the CRC screening population criteria if they were asymptomatic, were older than 50, and had no personal or familial history of colorectal neoplasia. The primary outcome was accuracy for the detection of polyps >= 6 mm. Secondary outcomes were accuracy for all polyps, polyps >= 10 mm, adenomas >= 10 mm, and cancers, the quality of bowel cleansing, safety, and CCE2 acceptability by the screening population. Results. A total of 236 individuals were examined; 11 patients (5%) were excluded. Therefore, 225 subjects (95%) were considered in the intention-to-screen (ITS) group. A total of 201 patients (89%) completed both examinations successfully (per protocol group). In the ITS group, polyps were diagnosed during CC in 114 subjects (51%); polyps >= 6 mm, polyps >= 10 mm, and adenomas >= 10 mm were diagnosed in 34 (15%), 16 (7%), and 11 (5%) patients, respectively. The sensitivity of CCE2 for polyps >= 6 mm, polyps >= 10 mm, and adenomas >= 10 mm was 79% (95% confidence interval (CI): 62-91%), 88% (95% CI: 62-98%), and 100% (95% CI: 72-100%), respectively. Conclusion. Second-generation capsule colonoscopy is a safe, noninvasive, and sensitive method for colorectal neoplasia detection although CC remains the preferred method for considerable proportion of subjects. CCE2 may therefore be accepted as the primary screening test for colorectal cancer screening.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

GASTROENTEROLOGY RESEARCH AND PRACTICE

ISSN

1687-6121

e-ISSN

1687-630X

Volume of the periodical

2019

Issue of the periodical within the volume

SEP 3 2019

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

000486404300001

EID of the result in the Scopus database

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