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Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA2202CMD" target="_blank" >RIV/61988987:17110/21:A2202CMD - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.semcancer.2020.06.001" target="_blank" >http://dx.doi.org/10.1016/j.semcancer.2020.06.001</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.semcancer.2020.06.001" target="_blank" >10.1016/j.semcancer.2020.06.001</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes

  • Original language description

    Decades of research have shown that rare highly penetrant mutations can promote tumorigenesis, but it is still unclear whether variants observed at high-frequency in the broader population could modulate the risk of developing cancer. Genome-wide Association Studies (GWAS) have generated a wealth of data linking single nucleotide polymorphisms (SNPs) to increased cancer risk, but the effect of these mutations are usually subtle, leaving most of cancer heritability unexplained. Understanding the role of high-frequency mutations in cancer can provide new intervention points for early diagnostics, patient stratification and treatment in malignancies with high prevalence, such as breast cancer.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    SEMINARS IN CANCER BIOLOGY

  • ISSN

    1044-579X

  • e-ISSN

    1096-3650

  • Volume of the periodical

  • Issue of the periodical within the volume

    72

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    175-184

  • UT code for WoS article

    000651883400002

  • EID of the result in the Scopus database

    2-s2.0-85090937155