Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA2202CMD" target="_blank" >RIV/61988987:17110/21:A2202CMD - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.semcancer.2020.06.001" target="_blank" >http://dx.doi.org/10.1016/j.semcancer.2020.06.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.semcancer.2020.06.001" target="_blank" >10.1016/j.semcancer.2020.06.001</a>
Alternative languages
Result language
angličtina
Original language name
Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes
Original language description
Decades of research have shown that rare highly penetrant mutations can promote tumorigenesis, but it is still unclear whether variants observed at high-frequency in the broader population could modulate the risk of developing cancer. Genome-wide Association Studies (GWAS) have generated a wealth of data linking single nucleotide polymorphisms (SNPs) to increased cancer risk, but the effect of these mutations are usually subtle, leaving most of cancer heritability unexplained. Understanding the role of high-frequency mutations in cancer can provide new intervention points for early diagnostics, patient stratification and treatment in malignancies with high prevalence, such as breast cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
SEMINARS IN CANCER BIOLOGY
ISSN
1044-579X
e-ISSN
1096-3650
Volume of the periodical
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Issue of the periodical within the volume
72
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
175-184
UT code for WoS article
000651883400002
EID of the result in the Scopus database
2-s2.0-85090937155