Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F19%3AA20021S1" target="_blank" >RIV/61988987:17310/19:A20021S1 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/19:00520373 RIV/60076658:12310/19:43899451 RIV/00216208:11310/19:10397938
Result on the web
<a href="https://mbio.asm.org/content/mbio/10/4/e01541-19.full.pdf" target="_blank" >https://mbio.asm.org/content/mbio/10/4/e01541-19.full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/mBio.01541-19" target="_blank" >10.1128/mBio.01541-19</a>

Result language
angličtina
Original language name
Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes
Original language description
We report frequent losses of components of the classical nonhomologous end joining pathway (C-NHEJ), one of the main eukaryotic tools for end joining repair of DNA double-strand breaks, in several lineages of parasitic protists. Moreover, we have identified a single lineage among trypanosomatid flagellates that has lost Ku70 and Ku80, the core C-NHEJ components, and accumulated numerous insertions in many protein-coding genes. We propose a correlation between these two phenomena and discuss the possible impact of the C-NHEJ loss on genome evolution and transition to the parasitic lifestyle. IMPORTANCE Parasites tend to evolve small and compact genomes, generally endowed with a high mutation rate, compared with those of their free-living relatives. However, the mechanisms by which they achieve these features, independently in unrelated lineages, remain largely unknown. We argue that the loss of the classical nonhomologous end joining pathway components may be one of the crucial steps responsible for characteristic features of parasite genomes.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30310 - Parasitology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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