Global analysis of inverted repeat sequences in human gene promoters reveals their non-random distribution and association with speci fic biological pathways

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21027WP" target="_blank" >RIV/61988987:17310/20:A21027WP - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/20:00539353 RIV/62156489:43110/20:43917709
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S088875431930850X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S088875431930850X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ygeno.2020.03.014" target="_blank" >10.1016/j.ygeno.2020.03.014</a>

Result language
angličtina
Original language name
Global analysis of inverted repeat sequences in human gene promoters reveals their non-random distribution and association with speci fic biological pathways
Original language description
Inverted repeats (IR) play important roles in specific DNA-dependent processes in simple prokaryotes to complex eukaryotes. They are recognized by a variety of proteins including restriction enzymes, helicases and transcription factors. We evaluate the presence and localization of IRs in all validated human promoter sequences within 1000 bp upstream and downstream of the transcription start site (TSS). The occurrence of 7 bp and longer IRs is located non-randomly in promoter regions, with enrichment within 200 bp upstream of the TSS. The highest frequency of IRs is just before TSS for repeats of 8 bp or longer. A comparison of promoters divided according to the occurrence of five individual promoter motifs shows unique location patterns of IRs. Principal component analyses and hierarchical clustering of IRs abundance demonstrated that they are depleted and/or not enriched in the promoters of stably expressed genes, but show significant enrichments for specific dynamically regulated biological pathways.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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