Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27740%2F14%3A86092431" target="_blank" >RIV/61989100:27740/14:86092431 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/14:43872693 RIV/61989100:27640/14:86092431

Result on the web

<a href="http://www.mdpi.com/1420-3049/19/11/17848" target="_blank" >http://www.mdpi.com/1420-3049/19/11/17848</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules191117848" target="_blank" >10.3390/molecules191117848</a>

Result language

angličtina

Original language name

Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique

Original language description

One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low intestinal permeability. Eighteen samples of risedronate sodium were prepared by the solvent evaporation technique with sodium dodecyl sulfate, polysorbate, macrogol, sodium carboxymethyl cellulose and sodium carboxymethyl dextran as nanoparticle stabilizers applied in three concentrations. The prepared samples were characterized by dynamic light scattering and scanning electron microscopy. Fourier transform mid-infrared spectroscopy was used for verification of the composition of the samples. The particle sizeof sixteen samples was less than 200 nm. Polysorbate, sodium carboxymethyl dextran and macrogol were determined as the most favourable excipients; the particle size of the samples of risedronate with these excipients ranged from 2.8 to 10

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

17848-17861

UT code for WoS article

000345564300045

EID of the result in the Scopus database

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