Preparation of Hydrochlorothiazide Nanoparticles for Solubility Enhancement

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27360%2F16%3A86098545" target="_blank" >RIV/61989100:27360/16:86098545 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/16:43874576 RIV/61989100:27640/16:86098545 RIV/61989100:27740/16:86098545

Result on the web

<a href="http://www.mdpi.com/1420-3049/21/8/1005/htm" target="_blank" >http://www.mdpi.com/1420-3049/21/8/1005/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules21081005" target="_blank" >10.3390/molecules21081005</a>

Result language

angličtina

Original language name

Preparation of Hydrochlorothiazide Nanoparticles for Solubility Enhancement

Original language description

Nanoparticles can be considered as a useful tool for improving properties of poorly soluble active ingredients. Hydrochlorothiazide (Class IV of the Biopharmaceutical Classification System) was chosen as a model compound. Antisolvent precipitation-solvent evaporation and emulsion solvent evaporation methods were used for preparation of 18 samples containing hydrochlorothiazide nanoparticles. Water solutions of surfactants sodium dodecyl sulfate, Tween 80 and carboxymethyl dextran were used in mass concentrations of 1%, 3% and 5%. Acetone and dichloromethane were used as solvents of the model compound. The particle size of the prepared samples was measured by dynamic light scattering. The selected sample of hydrochlorothiazide nanoparticles stabilized with carboxymethyl dextran sodium salt with particle size 2.6 nm was characterized additionally by Fourier transform mid-infrared spectroscopy and scanning electron microscopy. It was found that the solubility of this sample was 6.5-fold higher than that of bulk hydrochlorothiazide.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/LQ1602" target="_blank" >LQ1602: IT4Innovations excellence in science</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

8

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

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UT code for WoS article

000382334600044

EID of the result in the Scopus database

2-s2.0-84982706291