Monocyte chemoattractant protein-1 in patients with peripheral arterial disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F04%3A00000834" target="_blank" >RIV/61989592:15110/04:00000834 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Monocyte chemoattractant protein-1 in patients with peripheral arterial disease
Original language description
Background: Chemokine-driven migration of inflammatory cells has been implicated in the pathogenesis of atherosclerotic conditions including peripheral arterial disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with coronary artery disease and in hypertensive patients. This study therefore investigated MCP-1 in patients with PAD.Methods: Serum MCP-1 was determined by enzymelinked immunosorbent assay in 36 healthy, control subjects and in 19 patients with PAD. Statisticalanalysis utilised the Mann /Whitney test and Spearman correlation (pB/0.05). Results: MCP-1 (pg/ml) was increased in patients compared with in controls (mean9/standard error of the mean: PAD group, 7489/60; control group, 4599/ 27; p /0.0001). MCP-1 levels tended to decrease with progressing disease. From atherosclerosis risk factors, diabetes inclined to increase MCP-1 levels; hypertension had no effect. Serum MCP-1 correlated with cholesterol, triglycerides, low-density lipoprotein but
Czech name
Chemokin MCP-1 u pacientů s ischemickou chorobou dolních končetin
Czech description
Chemicky vyvolaná migrace zánětlivých buněk byla implikována při patogenezi aterosklerotických stavů, včetně periferního arteriálního onemocnění (PAD). Hladina monocyt-chemoattractant proteinu-1 (MCP-1) se zvyšuje u pacientů s

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Project
<a href="/en/project/NI7308" target="_blank" >NI7308: Chemostatic cytokine MCP-1 and its receptors CCR2 and CCR5 in patients with atherosclerosis of coronary and peripheral arteries</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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