Self-renewal of Embryonic Stem Cells: Cell Cycle Regulation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33143017" target="_blank" >RIV/61989592:15110/12:33143017 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-94-007-2993-3_2" target="_blank" >http://dx.doi.org/10.1007/978-94-007-2993-3_2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-94-007-2993-3_2" target="_blank" >10.1007/978-94-007-2993-3_2</a>

Result language
angličtina
Original language name
Self-renewal of Embryonic Stem Cells: Cell Cycle Regulation
Original language description
Embryonic stem cells (ESCs) have an unusual cell cycle structure with a short G1 phase and with the largest proportion of cells in the S phase. During differentiation, the ESC cycle is readily remodeled and a prominent G1 phase is established. Recently,prolongation of G1 phase has been shown to be sufficient to induce ESC differentiation and, on the other hand, remodeling of cell cycle to an ESC-like cell cycle has been found to be a crucial and rate-limiting step in the process of reprogramming of differentiated cells to induced pluripotent stem cells. The specific structure of ESC cycle has been suggested to be a general requirement for pluripotency and self-renewal and existence of several links between cell cycle machinery and core pluripotency factors has been proposed.
Czech name
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Czech description
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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