Biotransformation of Silybin and its Congeners
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146000" target="_blank" >RIV/61989592:15110/13:33146000 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/13:00423434
Result on the web
<a href="http://www.eurekaselect.com/118087/article" target="_blank" >http://www.eurekaselect.com/118087/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389200214666131118234507" target="_blank" >10.2174/1389200214666131118234507</a>
Alternative languages
Result language
angličtina
Original language name
Biotransformation of Silybin and its Congeners
Original language description
Silybin and its congeners belong to a group of flavonolignans with strong biological activities. These compounds are potentially applicable in human medicine, e. g. due to their cytoprotective activity. As a part of herbal preparations available on the open market, they face the risk of potential negative drug-drug interactions. This review aims to evaluate current knowledge on the metabolism of these compounds by biotransformation enzymes, interactions with other drugs, their pharmacokinetics, and bioavailability. While silybin and its derivatives interact with cytochrome P450s, only metabolism of silybin by cytochrome P450 2C8 poses a risk of adverse effects. The main biotransformation route of silybin and derivatives was identified as conjugation, which is sterospecific in case of silybin. Studies of the metabolism, pharmacokinetics, potentional drug - drug interactions 26 and increasing bioavailability of these flavonolignans play an important facet of possible therapeutical use of
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Drug Metabolism
ISSN
1389-2002
e-ISSN
—
Volume of the periodical
14
Issue of the periodical within the volume
10
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
13
Pages from-to
1009-1021
UT code for WoS article
—
EID of the result in the Scopus database
—